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Lithium Orotate


  • Lithium orotate Promotes a Positive Mental Outlook
  • Supports Detoxification Enzymes in the Brain
  • Boosts Neurotransmitter Activity

Lithium Orotate 60 caps (270060)


Though its exact mechanism of action in the brain is still unidentified, lithium has been shown in the research to boost neurotransmitter activity, including that of dopamine and serotonin, and to reduce the activity of the excitatory brain chemical glutamate. It also plays a role in the gene expression of natural detoxification enzymes in the brain, including glutathiones-transferase, offering important brain antioxidant protection, contributing to better cognitive health and memory. Other research has shown it to increase DHA in the brain, and even to promote cognitive longevity.

Lithium orotate is the lithium salt of orotic acid, commonly used to boost mood. This formulation of Lithium Orotate includes 10 mg per capsule for a wide range of protocols.

Lithium deficiency in certain insulin-sensitive tissues may be associated with blood sugar imbalance [2]. Low levels have been found in children with developmental delay, and individuals

Neurotransmitter and Mood Support†
Lithium is thought to help regulate the neurotransmitter glutamate by keeping the amount of glutamate between brain cells at a stable, healthy level to support healthy brain function. The mineral has been shown to be neuroprotective and to prevent neuronal cell death from free radical stress, effectively protecting neurons from glutamate-induced, NMDA receptor-mediated free radical damage in animals. In effective doses, lithium reduces neurological deficits. [3,4] In animal models, lithium was also found to promote increased cytoprotective B-cell activity. [5] Research has also found using
lithium, in a long-term low-dose support, promotes healthy brain aging.[6]

Brain Detoxification Support†
Research has also shown lithium to support the brain’s natural detoxification process. It has shown potential as a neuroprotective agent against Aluminum-induced oxidative stress and shows promise to protect the brain against free radical damage. [7] In animal models, lithium increased intracellular glutathione levels and reduced oxygen metabolite damage, suggesting that it selectively boosts  glutathionedependent enzymes to protect against free radical stress. [8]

Suggested Use:

1 capsule per day or as recommended by your health care professional


Lithium orotate is the lithium salt of orotic acid and is commonly used to promote a positive mood. In addition to supporting a healthy outlook and emotional wellness, low dosages of lithium orotate have been shown in research to support the brain’s natural detoxification process, provide antioxidant support, and promote the natural balance of neurotransmitters in the brain.



Lithium orotate is used in treating alcoholism.

Weight 14 oz
Dimensions 4 × 4 × 4 in

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