SAMe 60 caps (513060)
OVERVIEW: S-Adenosylmethionine (SAMe) is the active methyl form of the amino acid methionine. SAMe is necessary for an array of biochemical pathways, including neurotransmitter synthesis, metabolism of homocysteine, and detoxification. As a donator of methyl groups, SAMe supports glutathione production, liver health, musculoskeletal and joint comfort, and a positive mood.
- Provides Mood Support
- Supports Musculoskeletal Health
- Supports Liver Health
1-2 capsules two times per day or as recommended by your health care professional.
SAMe is a principle methyl donor for biochemical reactions throughout the body. This methyl transfer, is critical to reactions involving proteins, phospholipids, DNA, RNA, creatine, hormones, development of cell membranes, degradation of histamine, and formation of norepinephrine and dopamine.
Folate is a water-soluble member of the B-complex vitamins that is critical for maintaining optimal methylation pathways. Malabsorption and genetic defects in the enzyme 5-methyltetrahydrofolate reductase (5-MTHFR) can result in an impaired ability to activate folic acid. Folic acid supports the trans-methylation pathway, which metabolizes homocysteine into cysteine. Increases in oxidative stress may shift homocysteine metabolism towards trans-sulfuration to increase hepatic production of reduced glutathione.
*According to Mayo Clinic be cautious of the following possible interactions.
Possible interactions include:
- Antidepressants and other drugs and supplements that increase levels of serotonin. Don’t take SAMe with antidepressants. The combination could cause effects similar to a condition caused by high levels of the chemical serotonin to accumulate in your body (serotonin syndrome).
- Antipsychotics. Be cautious when taking these drugs with S-Adenosylmethionine. The combination could increase the risk of serotonin syndrome.
- Amphetamines. Be cautious when taking these drugs with S-Adenosylmethionine. The combination could increase the risk of serotonin syndrome.
- Dextromethorphan. Taking SAMe with this cough suppressant could increase the risk of serotonin syndrome.
- Levodopa. SAMe might reduce the effectiveness of levodopa (Inbrija), a medication used to treat Parkinson’s disease.
- Narcotics. Taking SAMe with meperidine (Demerol) or tramadol (Ultram, ConZip) could increase the risk of serotonin syndrome.
- St. John’s wort. Be cautious when taking this supplement with SAMe. The combination could cause serotonin syndrome.