UroProtect Px 60 caps (1350-U)

• UroProtect Px combines 1000 mg D-Mannose plus concentrated cranberry extract to support urinary tract health.
• Promotes healthy microbial balance in the urinary tract.
• Maintains a healthy mucosal surface in the urinary tract.

• Supplement Facts

  Serving Size: 2

  Servings Per Container: 30

  Suggested Use: Adults take 1-2 caps twice daily, with or without food, or as directed by healthcare practitioner.

  Ingredients	Amount Per Serving	% Daily Value
  Calories	5
  Total Carbohydrates	2 g	1%*
  Vitamin C (as Ascorbic Acid)	30 mg	33%
  D-Mannose	1,000 mg	†
  Cranberry Fruit Extract (37:1) Proanthocyanidins 16mg	400 mg	†
  * Percent Daily Values are based on a 2,000 calorie diet † Daily Value (DV) not established

  Ingredient Science: Cranberry ExtractD-Mannose

  Other Ingredients: Vegetable Cellulose Capsule

  This product is free of GMO, Gluten, wheat, saturated fats, sugar, dairy, yeast, and corn.

  Two Natural Ingredients to Effectively Treat Urinary Tract Infections

  

  Source: Restorative Medicine Digest

  July 14, 2025

  Cranberry Supplement Significantly Reduces Recurrent UTIs in Women

  A 6-month randomized, double-blind, placebo-controlled trial published in The American Journal of Clinical Nutrition evaluated the effects of whole cranberry fruit powder in women with recurrent urinary tract infections (UTIs). In the study, 150 women with a history of ≥3 UTIs in the past year or ≥2 in the past 6 months received either 500 mg of whole cranberry powder or placebo daily.

  At the end of the trial, women taking cranberry experienced a 52% reduction in culture-confirmed UTIs, and a 51% drop in E. coli-related infections. Symptomatic UTIs with frequency and urgency were reduced by 71%, with a 59% decrease in average total UTIs per participant. No serious adverse events were reported.

  These findings align with previous research, including a meta-analysis in the Journal of Nutrition showing a 26% reduced UTI risk in women using cranberry products. The reduction in E. coli suggests cranberry’s anti-adhesive properties in the bladder may be the key mechanism—an important consideration, as E. coli is detectable in most UTI cases, even when cultures are negative.

  D-Mannose May Reduce Recurrent UTIs with Minimal Side Effects

  A recent systematic review and meta-analysis evaluated the effectiveness of D-mannose in preventing recurrent urinary tract infections (UTIs) in adult women. Researchers screened over 700 studies and included eight that met criteria, focusing on women using D-mannose as an outpatient preventive treatment. Three studies qualified for meta-analysis, including randomized controlled trials and prospective cohort studies.

  Results showed that D-mannose significantly reduced UTI recurrence compared to placebo, with a pooled relative risk of 0.23 (95% CI, 0.14–0.37). When compared to antibiotics, D-mannose showed a relative risk of 0.39 (95% CI, 0.12–1.25), suggesting similar protective effects, though study variability was high. Importantly, D-mannose was well tolerated, with only one study reporting mild side effects (8 out of 103 participants experienced diarrhea). Compliance rates were high in the two studies that reported them.

  Citations

  https://pubmed.ncbi.nlm.nih.gov/39863114

  https://pubmed.ncbi.nlm.nih.gov/32497610

  DOI: https://doi.org/10.14200/rmd.2025.0004