Alpha GABA 90 caps (20057)

Alpha GABA containts ingredients to promote calm during times of anxiousness while supporting a healthy response to stress, day or night*
Patient Profile†
… Need to “downshift” from feeling mentally engaged*
… Feelings of anxiousness, seeking to restore relaxation and calm*
… Desire for help balancing stress*

Alpha GABA Key Ingredients
„ Amino acid that acts as a glutamate receptor antagonist for balanced activity1
*
„ L-theanine has been linked to the generation of alpha brain waves, indicating a state of restored relaxation2
*
„ Patented ashwagandha leaf and root extract that provides the highest amount of withanolides on the market (>10% withanolides)
„ Research and multiple data sets indicate Sensoril reduced stress and anxiousness3
*
„ Botanical shown to bind to the GABA site of GABA-A receptors for healthy activity4
*
„ Activation of GABA-A receptors are essential for downregulating the hypothalamic-pituitary-adrenal (HPA) axis5
*
„ Neuroprotective amino acid that provides antioxidant protection7,8*
„ Demonstrates healthy GABA-A agonist activity9
*
L-theanine
Ashwagandha (Withania somnifera)
Passionflower (Passiflora incarnata)
L-taurine
Lemon balm (Melissa officinalis)
„ Botanical shown to inhibit the enzyme
GABA transaminase to restore balance, which may increase healthy levels of GABA in the brain6
* Green = Biomarker
Blue = Enzyme
Orange = Cofactor
Glutamine
Succinate
Semialdehyde
Glutamate GABA
Citric
Acid
Cycle
glutamine
synthetase
glutaminase
glutamate
decarboxylase
Vitamin B6
Vitamin B6
glutaminase
GABA transaminase
succinate
semialdehyde
dehydrogenase
GABA Pathway
The Science
GABA is the primary inhibitory neurotransmitter in the brain10
„ GABA is important for calm and sleep11,12
Glutamate is the primary excitatory neurotransmitter in the brain13
„ Glutamatergic signaling underlies mechanisms related to anxiousness and stress14
Copyright © 2023 NeuroScience 100724-N2031
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Stress processing and balancing the symptom cycle
Stress, GABA, and the HPA axis
„ GABA signaling inhibits corticotropin-releasing hormone (CRH)
and glutamate signaling stimulates CRH15
„ Stress increases CRH secretion, stimulating the hypothalamic pituitary adrenal (HPA) axis and adrenal gland production of cortisol and the catecholamines15
„ Chronic stress causes neuroplastic changes in the paraventricular nucleus, decreasing GABA receptor expression and increasing glutamate receptor expression, perpetuating the stress response5
Alpha GABA provides a multi-faceted approach to stress management with ingredients to balance symptoms of anxiousness while supporting a healthy stress response3,5*