Curalieve 60 caps (13772) and 120 caps (14670)

ADVANCED ABSORPTION CURCUMIN

Integrative Therapeutics Curalieve provides advanced absorption curcumin due to its amorphous structure and excipient profile, which contributes to enhanced dispersibility and bioavailability. Curcumin has been studied and evaluated for its role in supporting antioxidant pathways and its effects on the body.*^1,2 Curalieve’s key ingredient is curcuRouge®, an amorphous solid dispersion of curcumin.

HOW IT WORKS

Generally, in humans, curcumin is very poorly absorbed. Curalieve is formulated with curcuRouge®. It is an amorphous solid dispersion containing curcumin extract. Comparatively, native curcumin has a propensity to form a crystalline structure that repels water. This crystalline structure is why consumption of native curcumin, even in gram amounts, yields little change in blood curcumin levels.³

Absorption

The technology used to develop curcuRouge overcomes these challenges by first melting curcumin to reduce the crystalline structure, then rapidly dispersing the curcumin with food-based polymers. curcuRouge has a smaller particle size and improved dispersibility as compated to native curcumin.

In addition, the amorphous nature of curcuRouge contributes to its enhanced dispersibility, higher bioavailability as shown in both animal and human research.⁴

Bioavailability

Specifically, in a single-dose, double-blind, two-way crossover study, curcuRouge exhibited a higher bioavailability compared to submicron-particle colloidal dispersion.⁵

• Firstly, curcuRouge was over 3 times more bioavailable than submicron-particle colloidal dispersion.
• Secondly, the maximal concentration (Cmax) of curcumin reached in the blood was over 5 times greater with curcuRouge compared to submicron-particle colloidal dispersion.
• Thirdly, curcuRouge was absorbed significantly faster than submicron-particle colloidal dispersion.

REFERENCES

1. 1.) Li H, Sureda A, Devkota HP, et al. Biotechnol Adv. 2020;38:107343. doi:10.1016/j.biotechadv.2019.01.010
2. 2.) Gautam SC, Gao X, Dulchavsky S. Adv Exp Med Biol. 2007;595:321-341. doi:10.1007/978-0-387-46401-5_14
3. 3.) Lao, C. D., Ruffin, M. T., 4th, Normolle, D., Heath, D. D., Murray, S. I., Bailey, J. M., Boggs, M. E., Crowell, J., Rock, C. L., & Brenner, D. E. (2006). BMC complementary and alternative medicine, 6, 10. https://doi.org/10.1186/1472-6882-6-10
4. 4.) Wegiel, LA et al., Pharmaceutical Development and Technology, 2014; 18(8): 976-986. DOI: 10.3109/10837450.2013.846374
5. 5.) Yoichi Sunagawa, Yusuke Miyazaki, et al. Journal of Functional Foods, Volume 81, 2021, 104443, ISSN 1756-4646, https://doi.org/10.1016/j.jff.2021.104443\

   Ingredients

   Serving Size: 2 capsule

   Amount/Serving

   %DV

   Total Carbohydrate

   …

   <1%

   curcuRouge® enhanced bioavailable, amorphous curcumin extract from Curcuma longa rhizome

   450 mg

   **

   ** Daily Value (DV) not established

   †Percent daily value is based on a 2000 calorie diet

   Other Ingredients

   cellulose, plant-derived capsule (hypromellose), food starch-modified, calcium stearate, silica

   Curalieve Does Not Contain

   • Wheat

   • Gluten

   • Soy

   • Dairy

   • Artificial Flavors

   Other Details

   curcuRouge® is a registered trademark of Therabiopharma, Inc. and is used under license.

   Directions

   Curalieve Directions and/or Dosage

   Adults take 2 capsules daily. Do not exceed recommended dose.

   Warning

   Do not take if you are pregnant or nursing. If you have gallstones, a bile duct obstruction, or if you are taking any medications, consult a healthcare professional before use.

   Keep out of reach of children.

   Safety sealed with inner seal. Do not use if seal is broken or missing. Keep tightly closed. Store at room temperature. Avoid excessive heat and direct sunlight.