Patient One Saffro-Calm Plus oral spray is formulated with a unique and synergistic combination of botanicals to calm feelings of occasional stress without drowsiness. Because the botanicals in Saffro-Calm Plus have been shown to interact with the body’s endocannabinoid system (ECS), this formula is part of our ECS Synergy™ series.

Our pleasant tasting spray is for oral use, to be taken by mouth, and may be used by adults and adolescents. Saffro-Calm Plus is convenient to carry when on the go or to easily access on a bedside table. For best results use Saffro-Calm Plus consistently, morning and evening, approximately every 12 hours.

Key Ingredients

Affron® Saffron, in more than 5 published human clinical studies, has been shown as effective at a low daily dose of 28 mg to calm occasional irritability and stress, promote mental balance, maintain a healthy mood and to support restful sleep. Made from Spanish saffron (Crocus sativus), affron’s patented formulation is standardized to provide 3.5% Lepticrosalides®, a complex of bioactive compounds.

Affron’s dual mechanisms of action include:

• reuptake inhibition of dopamine, norepinephrine and serotonin, increasing the concentration of these neurotransmitters in the synaptic cleft of neurons, thereby improving mood balance, and
• antioxidant effect against the excessive oxidative stress produced during the stress process in the central nervous system.

Scientific studies have associated saffron with modulation of the body’s endocannabinoid system.

Echinacea Angustifolia is also included for added support in reducing occasional tension and promoting a relaxed, positive mood. While this herb is commonly associated with immune system support, the root extract in our formula contains alkamides along with echinacosides. It has been shown that alkamides bind significantly to and activate the body’s cannabinoid receptors in the ECS.

Alkamides are bioactive compounds that show structural similarity with anandamide. Anandamide is a neurotransmitter that binds to cannabinoid receptors in the brain and body, stimulating a sense of happiness and mental balance. Anandamide is a little-known brain chemical that’s been called the “bliss molecule” for the role it plays in producing feelings of happiness.