Thyroid Zen Defense 120 caps (77500)

Thyroid Zen Defense provides Targeted Thyroid and Stress Response Support with Adaptogens and Immune-Modulating Nutrients*

What It Does
This formula delivers clinically studied nutrients and botanicals that support thyroid function, stress resilience, and immune system balance.* It targets the intersection of the hypothalamic-pituitary-thyroid (HPT) axis and stress physiology to promote healthy hormone synthesis, immune surveillance, and adaptive responses.*

How It Works
• Holy Basil (Holixer® extract): Clinically shown to reduce perceived stress and support cortisol balance, this adaptogen helps buffer stress-related disruptions to the HPT axis.*[1]
• Myo-Inositol + Selenium: In combination, this duo has been shown in multiple trials to support thyroid hormone biosynthesis and regulation more effectively than selenium alone.*[2–5]
• Myo-Inositol: Supports iodine uptake and organification, essential for thyroid hormone production in thyrocytes.*[4]
• Selenium: A cofactor for deiodinase and antioxidant enzymes (glutathione peroxidases, thioredoxin reductases), selenium protects thyroid tissue from oxidative stress and modulates immune signaling.*[5–7]
• Shiitake Mushroom (Lentinula edodes): Provides immunomodulatory beta-glucans and polysaccharides that influence natural killer (NK) cell activity, supporting immune surveillance and thyroid-immune interaction.*[8,9]
• Immune-Thyroid Interactions: NK cell activity plays a regulatory role in thyroid function, particularly during aging and times of immune activation.*[10]

Who It’s For
Designed for individuals seeking stress resilience and thyroid balance, particularly those seeking optimal thyroid health, stress response balance, or immune-thyroid axis support.*

Special Features
Provides a cohesive formula aimed at the triad of stress, thyroid, and immune health.*

References
1. Lopresti AL, et al. Front Nutr. 2022;9:965130. doi:10.3389/fnut.2022.965130
2. Ferrari SM, et al. Eur Rev Med Pharmacol Sci. 2017;21(2 Suppl):36–42.
3. Pace C, et al. Endocr J. 2020;67(11):1093–1098.
4. Paparo SR, et al. Front Endocrinol (Lausanne). 2022;13:930756. doi:10.3389/fendo.2022.930756
5. Nordio M, Basciani S. Eur Rev Med Pharmacol Sci. 2017;21(2 Suppl):51–59.
6. Wang F, et al. Front Endocrinol (Lausanne). 2023;14:1133000. doi:10.3389/fendo.2023.1133000
7. Pirola I, et al. Endocrinol Diabetes Nutr (Engl Ed). 2020;67(1):28–35.
8. Bisen PS, et al. Curr Med Chem. 2010;17(22):2419–2430.
9. Roszczyk A, et al. Int J Mol Sci. 2022;23(16):8980. doi:10.3390/ijms23168980
10. Lee EK, Sunwoo JB. Endocrinol Metab (Seoul). 2019;34(2):132–137